PadoBiom® analyses the subgingival microbiome using NGS (Next Generation Sequencing) considering over 7000 taxonomies– including bacteria, fungi, viruses and parasites – and 750 oral microorganisms in order to calculate a dysbiosis index based on more than 120 disease- and health-associated bacteria. The analysed parameters also include 23 relevant antibiotic resistance genes from 5 antibiotic classes. The dysbiosis index examines the balance between bacteria for health and disease. Furthermore, an algorithm calculates the risk of progression of periodontitis and can therefore indicate a likely progression of the disease.
Do I use mouthwash too often or too rarely? Is my brush achieving the desired results? Daily oral hygiene can be organised more efficiently with PadoBiom®.
Even more important is the use of PadoBiom® as a prophylaxis tool. By recognising a microbial imbalance (dysbiosis) at an early stage, measures can be taken to prevent the development of periodontitis resulting in tooth loss or to prevent its progression. These measures include intensified prophylaxis and more efficient oral hygiene, as well as supplements such as probiotics and vitamin D3.
PadoBiom® provides important support in the evaluation of clinical symptoms. This allows a better assessment of whether antibiotics are additionally indicated in the case of existing periodontitis.
PadoBiom® analyses the entire microbiome, i.e., all the genetic information contained in the respective sample. This means that not only are individual bacteria searched for and the rest excluded, but all recognizable DNA information is examined.
Microbiome analyses are regarded as a pioneering method. Analysing for individual bacterial causes in periodontal disease is considered outdated.
Scientific findings, the scope of analysis and unique evaluation options make PadoBiom® particularly helpful and more meaningful than regular ‘bacterial tests’. In particular, the dysbiosis index and risk of progression (S3 treatment guidelines compliant) provide an optimal basis for treatment and prophylaxis decisions.
A shift in the microbiome towards imbalance (from healthy to disease-related microbiota) and the determined risk of probable progression of dysbiosis provide the basis for recommended therapeutic measures.
23 relevant antibiotic resistance genes from 5 antibiotic classes provide information on a possible treatment failure or treatment complication. The key parameters include richness, evenness, indicator bacteria and Aa serotypes. These parameters show the composition of the microbiome and indicate a possible conclusion.
Depending on the clinical patient profile, the PadoBiom® result is categorised as a check-up, prophylaxis or therapy. Check-up signals a healthy or stable microbiome. Prophylaxis recommends an intensification of prophylaxis measures with possibly more frequent professional tooth cleaning, better personal oral hygiene (dental floss, mouthwash...) or probiotics. Depending on the progression, purely mechanical measures (subgingival cleaning) or the indication for the administration of antibiotics (whether and which) are indicated as a treatment recommendation.
Dysbiosis
A shift in the microbiome towards imbalance, i.e., loss of beneficial microbiota or overgrowth of potentially pathogenic microbiota.
Microbiome
The community of all microorganisms living together in a particular environment.